Mar 10, 2006

Mice with glowing hearts shed light on living cells

There is the heart of gold, and then there is the heart that glows. Literally.

Cornell researchers have genetically engineered mice whose hearts glow with a green light every time they beat. The development gives researchers insights into how hearts develop in living mouse embryos and could improve our understanding of irregular heartbeats, known as arrhythmias, as well as open doors to observing cellular processes to better understand basic physiology and disease.

The technique for making living, functional cells fluoresce, or glow, when the concentration of calcium ions rise within cells, is described online at http://www.pnas.org/papbyrecent.shtml and is to be published in a future issue of Proceedings of the National Academy of Sciences

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